Suggested Reading

Berg 6th ed: Chp2: 2.6 folding (brief introduction)

Berg 5th ed: Chp3: 3.6 folding (brief introduction)

Required Reading

papers:

• SCIENCE VOL 296 14 JUNE 2002: Toxic Proteins in Neurodegenerative Disease
• NATURE VOL 426 18 DECEMBER 2003: Protein folding and misfolding
  • The fundamental mechanism of protein folding
  • Protein folding and misfolding in the cell

Simulation 1 ---Simulation 2--- Animation

In Class Activities

Discussion of papers

Some definitions

• endoplasmic reticulum
• golgi apparatus

Problems

Illustration of the process of protein folding. Chymotrypsin inhibitor 2 from pdb file 1LW6.